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We introduce and apply an elegant, contrastive genetic-epidemiological design – Maternal Half-Sibling Families with Discordant Fathers – to clarify cross-generational transmission of genetic risk to alcohol use disorder (AUD), drug abuse (DA) and major depression (MD). New publication in Psychological Medicine

https://www.lupop.lu.se/article/maternal-half-sibling-families-discordant-fathers-contrastive-design-assessing-cross-generational - 2025-11-13

Perfluoroalkyl substances (PFASs) are widespread, bioaccumulating, and persistent and show placental transfer. Emerging research indicates associations between prenatal exposure and low birth weight. The aim of this study was to assess the associations between first trimester exposure to PFASs and birth weight (BW) in the Swedish Environmental, Longitudinal, Mother and child, Asthma and allergy (S

https://www.lupop.lu.se/article/maternal-serum-levels-perfluoroalkyl-substances-early-pregnancy-and-offspring-birth-weight - 2025-11-13

Elderly patients with acute myocardial infarction undergoing percutaneous coronary intervention are at increased risk of both ischemic and bleeding complications. The optimal anticoagulation strategy in these patients is uncertain. Therefore, we compared bivalirudin to heparin monotherapy in a contemporary cohort of such patients. New publication in Circulation: Cardiovascular Interventions

https://www.lupop.lu.se/article/bivalirudin-versus-heparin-monotherapy-elderly-patients-myocardial-infarction-prespecified-subgroup - 2025-11-13

Incidence of ST-elevation myocardial infarction (STEMI) is increasing in Nepal. We aim to describe the presentation, management, complications, and outcomes of patients admitted with a diagnosis of STEMI in Shahid Gangalal National Heart Centre (SGNHC), Nepal. New publication in Nepalese Heart Journal

https://www.lupop.lu.se/article/shahid-gangalal-national-heart-centre-st-elevation-myocardial-infarction-registry-sgnhc-stemi - 2025-11-13

There has been considerable interest in recent years in quantifying the rate of unavoidable or so‐called random cancers, as opposed to cancers linked to environmental, genetic or other factors. We propose a data‐based approach to estimate an upper limit to this probability, based on an analysis of multiple registry data. The argument is that the cumulative hazards for random cancers cannot exceed

https://www.lupop.lu.se/article/random-cancers-supported-registry-data - 2025-11-13

Deidentified data from the Australasian Collaborative Trial of Magnesium Sulphate (ACTOMgSO4) and the ACPR were linked. Children born from 1996 to 2000 at Australian hospitals who survived and had 2‐year paediatric assessments were included. Children identified with CP in: (1) both the ACTOMgSO4 (2y) and the ACPR (5y), (2) the ACTOMgSO4 only, and (3) the ACPR only were compared. New publication in

https://www.lupop.lu.se/article/linking-data-large-clinical-trial-australian-cerebral-palsy-register - 2025-11-13

The aims were to investigate the association between maternal serum levels of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS) and perfluorononanoic acid (PFNA) in early pregnancy and overweight in the child at 4 years and to assess potential heterogeneity in exposure effect between strata with different levels of other risk factors for overweight.

https://www.lupop.lu.se/article/intrauterine-exposure-perfluorinated-compounds-and-overweight-age-4-case-control-study - 2025-11-13

Population-based administrative registers are often used for research purposes. However, their potential usefulness depends on the validity of the registered information. This study assessed the validity of the recorded codes for social anxiety disorder (SAD), also known as social phobia, in the Swedish National Patient Register (NPR). New publication in BMC Psychiatry

https://www.lupop.lu.se/article/validity-and-reliability-social-anxiety-disorder-diagnoses-swedish-national-patient-register - 2025-11-13

Quantified terminal ileal motility during magnetic resonance enterography (MRE) has been suggested to be used as a biomarker of Crohn's disease (CD). The aim of the present study was to evaluate this method in clinical practice. New publication in NGM

https://www.lupop.lu.se/article/volumetric-analysis-small-bowel-motility-unselected-cohort-patients-crohns-disease - 2025-11-13

Recovery patterns of motor function and activity capacity of the upper extremity after stroke have been described, but less is known about longitudinal changes of perceived manual activity performance. The aim of this study was to investigate longitudinal changes of self-perceived manual ability at several timepoints from onset until 12 months post-stroke in a cohort of consecutively recruited ind

https://www.lupop.lu.se/article/longitudinal-changes-self-perceived-manual-ability-first-year-after-stroke-cohort-study - 2025-11-13

Earlier studies have implied a change in dietary habits of the Swedish population towards a low carbohydrate, high fat diet. Questions have been raised about the development in recent years and potential health effects. We have investigated the dietary intake of Swedish female students enrolled in a university nutrition course between 2002 and 2017. The students carried out self-reporting of all f

https://www.lupop.lu.se/article/carbohydrates-fat-trends-food-intake-among-swedish-nutrition-students-2002-2017 - 2025-11-13

To evaluate screening efficiency and suggest cut-offs for parent and child Mood and Feelings Questionnaire (MFQ) and the short version (SMFQ) in unselected help seeking child- and adolescent psychiatric outpatients for subgroups of 6–12 versus 13–17 year olds and boys versus girls. New publication in PLOS ONE

https://www.lupop.lu.se/article/screening-efficiency-mood-and-feelings-questionnaire-mfq-and-short-mood-and-feelings-questionnaire - 2025-11-13

The outbreak of SARS-CoV-2 is the worst healthcare emergency of this century, and its impact on pediatrics and neonatology is still largely unknown. The European Society for Pediatric and Neonatal Intensive Care (ESPNIC) launched the EPICENTRE (ESPNIC Covid pEdiatric Neonatal Registry) international, multicenter, and multidisciplinary initiative to study the epidemiology, clinical course, and outc

https://www.lupop.lu.se/article/epicentre-espnic-covid-pediatric-neonatal-registry-initiative-background-and-protocol-international - 2025-11-13

Pancreatic cancer is a devastating disease with a dismal prognosis. Despite profound medical advances in systemic therapies for other types of aggressive tumours during recent years, a diagnosis of pancreatic cancer is still often synonymous with a fatal outcome. The term periampullary cancer includes pancreatic cancer and applies to the group of tumours found in proximity to the ampulla of Vater.

https://www.lupop.lu.se/article/chemotherapy-host-response-and-molecular-dynamics-periampullary-cancer-champ-study - 2025-11-13

The real burden of human cystic echinococcosis (CE) remains elusive, due to the peculiar characteristics of the disease and the heterogeneous and incomplete data recording of clinical cases. Furthermore, official notification systems do not collect pivotal clinical information, which would allow the comparison of different treatment outcomes, and thus circumvent the difficulty of implementing clin

https://www.lupop.lu.se/article/european-register-cystic-echinococcosis-erce-state-art-five-years-after-its-launch - 2025-11-13

Sex offender registries (SORs) were established due to policies and practices intended to protect the public from individuals who commit sexually violent acts, and yet the empirical literature does not show that public SORs reduce or prevent sexual crimes. Given that politicians prominently influence SOR policies, the current study explores the views of SORs by 26 political decision-makers from Ca

https://www.lupop.lu.se/article/sex-offender-registries-exploring-attitudes-and-knowledge-political-decision-makers - 2025-11-13

We evaluated a structured education- and exercise-based self-management program for patients with knee or hip osteoarthritis (OA), using a registry-based study of data from 44,634 patients taken from the Swedish “Better Management of Patients with Osteoarthritis” registry. Outcome measures included a numeric rating scale (NRS), EuroQol five dimension scale (EQ-5D), Arthritis self-efficacy scale (A

https://www.lupop.lu.se/article/better-management-patients-osteoarthritis-program-outcomes-after-evidence-based-education-and - 2025-11-13

High-quality clinical research of resuscitations in a pediatric emergency department is challenging because of the limitations of traditional methods of data collection (chart review, self-report) and the low frequency of cases in a single center. To facilitate valid and reliable research for resuscitations in the pediatric emergency department, investigators from 3 pediatric centers, each with ex

https://www.lupop.lu.se/article/videography-pediatric-emergency-research-establishing-multicenter-collaborative-and-resuscitation - 2025-11-13

International research has found changes in how today’s young people evaluate themselves. The present Swedish research contributes with new findings by distinguishing different patterns of change in self-evaluation in two age groups. The study investigates generational and gender differences in five self-evaluation dimensions in two samples, one from 1983 (N = 3052 10–16-year-old students) and one

https://www.lupop.lu.se/article/self-evaluation-differences-among-swedish-children-and-adolescents-over-30-year-period - 2025-11-13

Pain treatment post orthopaedic care in the elderly is complicated and requires careful follow-up. Current guidelines state all patients prescribed opioids should have a plan for gradual reduction, with the treatment progressively reduced and ended if any pain remains after more than three months. How this works in primary care remains to be explored. The aim was to describe pain treatment and its

https://www.lupop.lu.se/article/descriptive-study-pain-treatment-and-its-follow-primary-care-elderly-patients-after-orthopaedic-care - 2025-11-13